Eisley was born on October 29, 1993, in Los Angeles, California, to musician David Glen Eisley and actress Olivia Hussey. Her grandfather was actor Anthony Eisley. Eisley and her mother appeared together in the movie Headspace (2005). After small roles in various independent films, Eisley gained a major role in The Secret Life of the American Teenager (2008). She played Ashley Juergens, younger sister of teen mother Amy Juergens.　　Eisley starred as Sawa in the action film Kite (2014), starring Samuel L. Jackson. At the end of 2014 she filmed Social Suicide (2015), a modern retelling of Romeo and Juliet. In the beginning of 2015 she also filmed the dark fantasy film The Curse of Sleeping Beauty (2016) as Briar Rose. Eisley also appears in the film adaptation of the VC Andrews' book My Sweet Audrina, in the title role of Audrina.

2003年，英迪娅·埃斯利首次以演员身份登场，她在母亲奥利维拉·赫西主演的电视电影《特里萨修女》里饰演了一个无名英国女孩。

2005年，她再次在母亲主演的电影里扮演角色，这次是在恐怖电影《顶空》里。

2008年，英迪娅·埃斯利加盟谢琳·伍德蕾主演的青春连续剧《青春密语》，剧中饰演了常驻角色AshleyJuergens，她参加了此剧第一季到第五季的拍摄。

2012年，她在动作电影《黑夜传说4》里饰演了女主角凯特·贝金赛尔女儿Eve，吸血鬼与狼人的混血儿。

2014年，英迪娅·埃斯利在改编自本cult动画的真人电影《少女杀手》里饰演女主角Sawa，片中和塞缪尔·杰克逊以暴制暴。